ENTERION CAPSULE PDF

Download Citation on ResearchGate | On Jan 1, , I.R. Wilding and others published The enterion capsule: A novel technology for understanding the. A remote controlled drug delivery capsule for use in absorption studies has been developed by a UK company. The new technology, called the Enterion capsule. Advances in combinatorial chemistry, proteomics, and genomics have led to the potential for an unprecedented number of new molecular.

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For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to cspsule cookies. To find relevant articles please visit here to pick a cluster. The Pharmaceutical Capsupe Vol No p May 27, Clinical Remote control capsule for absorption studies A remote controlled drug delivery capsule for use in absorption studies has been developed by a UK company.

The new technology, called the Enterion capsule, is being used by Pharmaceutical Profiles, an early phase development company. It was developed by Phaeton Research, a sister company to Pharmaceutical Profiles.

The capsule is designed to release drug at an exact target site in the gastrointestinal tract. Researchers can then measure the extent to which the drug is absorbed from different regions of the GI tract. The capsule is activated by fnterion radiofrequency signal, which releases a spring-controlled piston and leads to release of the capsule contents see Figure. The location of the capsule within the GI tract is tracked using gamma scintigraphy while the presence of a radiolabel within the drug reservoir allows visualisation capaule the drug in the GI tract following activation.

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The empty capsule is excreted. Dr Ian Wilding chief executive, Pharmaceutical Profiles said recently that many candidate drug molecules currently being developed had complex chemistry, poor solubility and limited permeability, which led to problems of delivering the drugs effectively to patients.

Traditional studies to measure absorption profiles tended to be carried out on products that were already formulated and the chosen formulation could turn out not to be ideal. With the new technology, which could test particulates and liquids, decisions on optimal drug delivery technology, or on whether the oral route was perhaps not suitable after all, could now be taken before too much time had been spent on formulation development.

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Remote control capsule for absorption studies | News | Pharmaceutical Journal

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Evaluation of regional gastrointestinal absorption of edoxaban using the enterion capsule.

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A radiofrequency signal releases a spring-controlled piston and the movement of the piston enterjon initiates rapid release of capsule contents into the target area.

The capsule is 32mm long. Have your say For commenting, please login or register as a user and agree to our Community Guidelines. Recommended from Pharmaceutical Press Previous Next.

Evaluation of regional gastrointestinal absorption of edoxaban using the enterion capsule.

Disease Management Disease Management covers the diseases enteion encountered in primary care by system, with common therapeutic issues.

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Capsule targets drug delivery within GI tract

Clinical Pharmacokinetics A practical guide to the use of pharmacokinetic principles in clinical practice. Enter email address Submit. A remote controlled drug delivery capsule for use in absorption studies has been developed by a UK company.